Animal models are often used for biochemistry research for obvious ethical reasons. Rats fed a ghee supplemented diet had reduced levels of thromboxane’s, leukotrienes and prostaglandins.
Our body produces these inflammatory compounds from polyunsaturated fats embedded into our cell membranes. The less inflammation, the lower your heart disease risks.
Even if you do avoid dairy, ghee shouldn’t present any problems and while it may not be strictly ‘paleo’, from the evidence base that does exist, it sits well with me from a health perspective. I regularly use ghee for frying at high heats.